Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The bile acid-gut microbiota-vitamin D axis: new insights into biliary atresia.

Frontiers in cellular and infection microbiology·2026
Same author

Rapid Water Diffusion through Extended Networks in MOFs.

Nano letters·2026
Same author

Opposing roles of serine and charge in IDR condensate miscibility.

Nature chemical biology·2026
Same author

Zwitterion-Modified Thermoresponsive Polymers for Nanopore Applications: A Mesoscopic Simulation Study.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Simulation Study of <i>Candida rugosa</i> Lipase Adsorption on Self-Assembled Monolayers.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Molecular Dynamics Insights into CO<sub>2</sub>/N<sub>2</sub> Separation by a Porous Organic Cage-Supported Ultrathin Imidazolium Ionic Liquid Layer.

Langmuir : the ACS journal of surfaces and colloids·2026

Related Experiment Video

Updated: Nov 6, 2025

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies
08:29

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies

Published on: January 19, 2016

11.5K

Lysozyme Adsorption on Different Functionalized MXenes: A Multiscale Simulation Study.

Daohui Zhao1, Chu Huang1, Xuebo Quan2

  • 1Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P.R. China.

Langmuir : the ACS Journal of Surfaces and Colloids
|May 7, 2021
PubMed
Summary
This summary is machine-generated.

Lysozyme protein adsorbs well onto functionalized 2D titanium carbide (Ti3C2Tx) surfaces. Oxygen-terminated Ti3C2Tx shows the strongest interaction, indicating potential for biocompatible material design.

More Related Videos

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

48.6K
Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

13.0K

Related Experiment Videos

Last Updated: Nov 6, 2025

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies
08:29

Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies

Published on: January 19, 2016

11.5K
Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

48.6K
Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

13.0K

Area of Science:

  • Materials Science
  • Biophysics
  • Surface Chemistry

Background:

  • Two-dimensional (2D) materials like MXenes offer unique properties for various applications.
  • MXenes, particularly titanium carbide (Ti3C2Tx), are explored for biosensing and energy storage.
  • Understanding protein-MXene interactions is crucial for biocompatible material development.

Purpose of the Study:

  • To investigate lysozyme adsorption on different functionalized Ti3C2Tx surfaces (-O, -OH, -F).
  • To determine the interaction strength and adsorption mechanisms.
  • To evaluate the biocompatibility of Ti3C2Tx materials for biorelated applications.

Main Methods:

  • Parallel tempering Monte Carlo simulations.
  • Molecular dynamics simulations.
  • Analysis of interaction forces (electrostatics, van der Waals) and interfacial water layer effects.

Main Results:

  • Lysozyme effectively adsorbs on Ti3C2Tx surfaces.
  • Interaction strength order: Ti3C2O2 > Ti3C2F2 > Ti3C2(OH)2.
  • Protein conformation remains stable, indicating good biocompatibility.
  • Interfacial water layer influences adsorption.

Conclusions:

  • Ti3C2Tx materials exhibit good biocompatibility for protein adsorption.
  • Surface functionalization significantly impacts adsorption strength and orientation.
  • These findings offer insights for engineering Ti3C2Tx surfaces in biomedical applications.