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Updated: Nov 6, 2025
Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
Published on: July 28, 2023
Overcoming translational barriers in modeling macular degenerations
Nicholas David Nolan1, Peter M J Quinn2, Stephen H Tsang3
1Jonas Children's Vision Care, Department of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA; Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Abstract:
Advances in tissue mimetics are paving the way for interrogating both the pathobiology of human disease and innovative therapeutic paradigms. In this issue of Cell Stem Cell, Manian et al. (2021) develop a novel iPSC-derived retinal pigment epithelium (RPE)-choriocapillaris (CC) complex that recapitulates key features of macular degenerations.
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