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Updated: Nov 6, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
SLiMs in intrinsically disordered protein regions regulate the cell cycle dynamics of ORC1-CDC6 interaction and
1Institute of Technology, University of Tartu, Tartu 50411, Estonia.
Abstract:
Hossain et al. (2021) show that human origin recognition complex subunit ORC1 and licensing factor CDC6 interact when the pre-replicative complex forms in G1. Short linear motifs (SLiMs) in intrinsically disordered regions (IDRs) mediate this interaction and its regulation by CDKs.
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