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Therapeutic approaches for SARS-CoV-2 infection
Ankur Gupta1, Anish Pradhan1, Vimal K Maurya2
1Government Pharmacy College, Sajong, Rumtek, Gangtok 737135, India.
Methods (San Diego, Calif.)
|May 7, 2021
Summary
Effective COVID-19 treatments are needed, as specific drugs remain unavailable. This review explores diverse therapeutic strategies, including drug discovery and complementary medicine, to combat SARS-CoV-2.
Area of Science:
- Virology
- Drug Discovery
- Immunology
Background:
- No specific antiviral drugs are currently available for COVID-19 treatment, despite ongoing research.
- Understanding the SARS-CoV-2 life cycle and host responses is crucial for developing effective therapies.
- Complementary and alternative medicine (CAM) shows potential in enhancing immune responses and patient resilience.
Purpose of the Study:
- To summarize and analyze various therapeutic antiviral strategies for COVID-19 drug discovery.
- To explore novel approaches including drug repurposing, natural products, and phage technology.
- To understand mechanistic pathways for targeting SARS-CoV-2 and host immunity.
Main Methods:
- Review of computer-aided drug design, including high throughput virtual screening (HTVS).
- Analysis of repurposed drugs, novel synthetic compounds, and natural product discovery.
- Examination of immunomodulators, vaccines, plasma therapy, and phage technology.
Main Results:
- Multiple therapeutic avenues are being investigated, ranging from small molecule inhibitors to advanced biotechnologies.
- Understanding host-pathogen interactions and host factors (nutrition, metabolism, lifestyle) informs therapeutic strategies.
- Integrated approaches combining conventional and CAM may offer improved outcomes.
Conclusions:
- A multifaceted therapeutic strategy is essential for effective COVID-19 containment.
- Continued research into drug discovery, repurposing, and immune modulation is vital.
- Exploring diverse approaches, including CAM, can enhance treatment efficacy and patient recovery.
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