Osteoarthritis: From upcoming treatments to treatments yet to come

Area of Science:

• Orthopedics
• Regenerative Medicine
• Biotechnology

Background:

• Osteoarthritis (OA) is a widespread degenerative joint disease with increasing prevalence.
• Current treatments manage symptoms but do not alter OA's disease course.
• Novel therapeutic targets and strategies are under investigation to address OA's unmet needs.

Purpose of the Study:

• To review promising and emerging therapeutic approaches for osteoarthritis.
• To highlight advancements in cell therapy, gene therapy, and biofabrication for OA treatment.
• To provide an outlook on future personalized OA management strategies.

Main Methods:

• Literature review of recent scientific publications and clinical trial data.
• Analysis of innovative therapeutic modalities for osteoarthritis.
• Synthesis of information on cell-based therapies, gene therapies, and biofabrication technologies.

Main Results:

• Cell therapies are advancing into clinical trials for osteoarthritis.
• Gene therapy presents new avenues for osteoarthritis treatment based on recent discoveries.
• 3D bioprinting offers potential for personalized OA models for drug screening and treatment.

Conclusions:

• Multiple promising therapeutic strategies are being developed for osteoarthritis.
• Innovative approaches like cell and gene therapy are nearing clinical application.
• Future biofabrication technologies may revolutionize personalized osteoarthritis care.