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Cortical responsive neurostimulation in a baboon with genetic generalized epilepsy
C Ákos Szabó1, Melissa De La Garza2, Robert Shade2
1Department of Neurology, UT Health San Antonio, San Antonio, TX, United States.
Epilepsy & Behavior : E&B
|May 7, 2021
Summary
Cortical responsive neurostimulation (CRN) reduced generalized tonic-clonic seizures by 38% in a baboon model of genetic generalized epilepsy (GGE). Treatment also altered seizure patterns and their daily rhythms, showing promise for epilepsy therapy.
Area of Science:
- Neuroscience
- Epileptology
- Animal Models
Background:
- Genetic Generalized Epilepsy (GGE) is a significant neurological disorder.
- Current treatments for GGE have limitations.
- Animal models are crucial for understanding epilepsy and testing new therapies.
Purpose of the Study:
- To evaluate the efficacy of Cortical Responsive Neurostimulation (CRN) in a baboon model of GGE.
- To assess treatment-induced alterations in seizure patterns and their circadian rhythms.
Main Methods:
- Implantation of subdural frontoparietal strips for electrocorticography (ECoG) monitoring.
- Daily ECoG data collection during baseline and treatment phases.
- Quantification of generalized tonic-clonic seizures (GTCS) and long epileptic episodes.
Main Results:
- A 38% median reduction in GTCS was observed with CRN therapy.
- Daily indices of long epileptic episodes decreased significantly.
- Ictal ECoG patterns and the circadian distribution of GTCS were altered by treatment.
Conclusions:
- CRN shows proof-of-concept efficacy in a baboon model of GGE.
- Treatment altered seizure characteristics and circadian patterns.
- Future research could explore combined cortical and subcortical stimulation for improved seizure control.
