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Blood rheology in IgA nephropathy
B I Shand1, R R Bailey, L O Simpson
1Department of Pathology, University of Otago Medical School, Dunedin, New Zealand.
Clinical Nephrology
|June 1, 1988
Summary
Blood rheology, including viscosity and red blood cell deformability, is altered in IgA nephropathy (IgAN). These changes may contribute to IgAN development and progression.
Area of Science:
- Nephrology
- Hematology
- Pathophysiology
Background:
- IgA nephropathy (IgAN) is a common glomerular disease.
- The role of blood rheology in IgAN pathogenesis is not fully understood.
Purpose of the Study:
- To investigate blood rheological properties in IgAN patients.
- To explore correlations between rheological parameters and clinical indices of IgAN.
Main Methods:
- Whole blood viscosity, red blood cell deformability, and plasma viscosity were measured.
- Comparison was made between 35 IgAN patients and age/sex-matched controls.
Main Results:
- Significant alterations in whole blood viscosity, red blood cell deformability, and plasma viscosity were observed in IgAN patients.
- A correlation was found between rheological determinants and clinical IgAN indices.
- The specific causes of these rheological abnormalities remain undefined.
Conclusions:
- Abnormal blood rheology is present in IgA nephropathy.
- Altered rheology may increase intraglomerular pressure and contribute to mesangial lesions.
- Abnormal blood rheology is proposed as a potential causal factor in IgAN pathogenesis.