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Related Concept Videos

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

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Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
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Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
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Bioavailability: Overview01:17

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Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
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Proteins: Dietary Sources and Requirements01:28

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Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
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Bioavailability: Influencing Factors01:22

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Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
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Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Related Experiment Video

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'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
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Perspective: Framework for Developing Recommended Intakes of Bioactive Dietary Substances.

Allison A Yates1, Johanna T Dwyer2, John W Erdman3

  • 1Agricultural Research Service/USDA (Retired), Johnson City, TN, USA.

Advances in Nutrition (Bethesda, Md.)
|May 7, 2021
PubMed
Summary

A new framework helps develop evidence-based intake recommendations for dietary bioactives, like omega-3 fatty acids. This ensures consumers receive reliable health information, promoting informed food choices.

Keywords:
diet and healthdietary bioactivesdietary reference intakesdietary supplementsfood sourcesrecommended intakesreference valuessystems for nutrition evidence reviews

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Area of Science:

  • Nutritional Science
  • Public Health
  • Evidence-Based Practice

Background:

  • Dietary bioactives, such as flavonoids and omega-3 fatty acids, offer health benefits beyond essential nutrition.
  • Current information on dietary bioactives often lacks standardization and rigor, leading to consumer confusion.
  • Evidence-based intake recommendations are needed for health professionals to guide consumers effectively.

Purpose of the Study:

  • To present a framework for developing quantified intake recommendations for dietary bioactives.
  • To ensure guidance is based on high-quality evidence, vetted for efficacy and safety.
  • To facilitate the communication of specific dietary bioactive amounts linked to health benefits.

Main Methods:

  • A 4-step framework adapted from clinical guideline development processes.
  • Characterizing bioactives, their food sources, and intake levels.
  • Evaluating safety, quantifying the bioactive-health relationship through systematic reviews, and translating evidence into intake statements.

Main Results:

  • The framework provides a structured approach to quantifying dietary bioactive recommendations.
  • It emphasizes the need for expert vetting of evidence for efficacy and safety.
  • The process accounts for the unique consideration that side effects are unacceptable for dietary bioactives.

Conclusions:

  • The proposed framework offers a model for credible health organizations to develop reliable dietary bioactive guidance.
  • This approach supports evidence-based recommendations for specific dietary compounds and their health benefits.
  • The framework is adaptable and can be updated with advancements in scientific approaches.