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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
Published on: December 8, 2023
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[Hematopoietic stem cell transplant yesterday and today]
Éliane Gluckman1, Hanadi Rafii1
1Hôpital Saint-Louis, AP-HP, Eurocord, 1 avenue Claude-Vellefaux, 75010 Paris, France.
Soins; La Revue De Reference Infirmiere
|May 8, 2021
Summary
Hematopoietic stem cell transplants (HSC) involve replacing diseased cells with healthy ones. This procedure uses chemoradiation followed by stem cell infusion from the patient or a donor.
Area of Science:
- Hematology
- Transplant Medicine
- Oncology
Background:
- Bone marrow transplantation, now known as hematopoietic stem cell (HSC) transplant, is a critical treatment modality.
- It is utilized for patients diagnosed with malignant hematologic diseases and other conditions.
- The procedure involves conditioning the patient followed by stem cell infusion.
Purpose of the Study:
- To define the hematopoietic stem cell (HSC) transplant procedure.
- To differentiate between autologous and allogeneic transplant approaches.
- To outline the core components of HSC transplantation.
Main Methods:
- Chemoradiation therapy to condition the patient.
- Infusion of hematopoietic stem cells (HSC).
- Utilizing either autologous (patient's own cells) or allogeneic (donor cells) sources.
Main Results:
- Successful engraftment of transplanted HSCs.
- Restoration of hematopoiesis and immune function.
- Disease control or cure in eligible patients.
Conclusions:
- Hematopoietic stem cell (HSC) transplantation is a complex but vital procedure.
- It offers therapeutic potential for various hematologic malignancies and non-malignant disorders.
- The choice between autologous and allogeneic HSC sources depends on the specific clinical context.
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