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Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay
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Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

Published on: April 28, 2014

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Vaccination rates and adherence in pneumococcal conjugate vaccination in mature born infants before and after

Maren Laurenz1, Christof von Eiff1, Kathrin Borchert2

  • 1Pfizer Pharma GmbH, Linkstraße 10, 10785 Berlin, Germany.

Vaccine
|May 8, 2021
PubMed

Insights

The German pneumococcal conjugate vaccination (PCV) 2+1 schedule saw a slight increase in booster rates but nearly a quarter of infants remained unvaccinated. Adherence to timely vaccination remains a challenge.

Area of Science:

  • Pediatrics
  • Public Health
  • Immunology

Background:

  • In August 2015, Germany's STIKO updated the infant pneumococcal conjugate vaccination (PCV) schedule from 3+1 to 2+1 doses.
  • This change aimed to improve vaccination acceptance by reducing the number of doses administered.

Purpose of the Study:

  • To evaluate PCV vaccination rates and adherence in infants following the 2015 schedule change.
  • To assess real-world data on infant vaccination uptake and timeliness.

Main Methods:

  • Retrospective analysis of claims data from the InGef Research Database.
  • Comparison of infant cohorts born in 2013 (3+1 schedule) and 2016 (2+1 schedule).
  • 24-month follow-up for vaccination status, including hexavalent vaccination (HEXA) as a reference.

Main Results:

  • PCV uptake at 24 months was high (90.9% for 2016 cohort).
  • Booster dose rates increased slightly (75.6% in 2016 vs. 67.7% in 2013), but 24.4% of 2016 infants did not receive a booster.
  • Timely booster vaccination rates remained low, with only 46.3% (2016) receiving it on schedule.

Conclusions:

  • The 2+1 PCV schedule did not fully resolve the issue of incomplete vaccination, with a significant proportion of infants missing the booster dose.
  • Vaccination delays persist, and the rate of unvaccinated infants remained unchanged.
  • Further strategies are needed to improve timely and complete PCV vaccination coverage.
Abstract

Keywords:
Claims data analysisHexavalent vaccinationMature newbornsPneumococcal conjugate vaccineVaccination rates

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