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Distinct lung function and bronchodilator responses between term and preterm young children with recurrent wheezing
Shen-Hao Lai1, Ming-Han Tsai2, Man-Chin Hua2
1Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung University, Taoyuan, Taiwan; Prediction of Allergies in Taiwanese Children (PATCH) Cohort Study, Keelung, Taiwan.
Pediatrics and Neonatology
|May 8, 2021
Summary
Young children with recurrent wheezing show reduced lung function. Term infants with wheezing had poorer lung function and greater bronchodilator response than preterm infants.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
Background:
- Recurrent wheezing is common in young children, particularly preterm infants.
- Infant lung function testing can differentiate wheezing phenotypes.
Purpose of the Study:
- To compare lung function in term versus preterm young children with recurrent wheezing.
- To assess bronchodilator responsiveness in these groups.
Main Methods:
- Recruited children under 2 years with >=3 wheezing episodes and healthy controls.
- Performed lung function tests: tidal breathing, passive mechanics, forced expiration.
- Repeated forced expiration post-bronchodilator in wheezing groups.
Main Results:
- 68 children (40 wheezing, 28 controls) enrolled; 23 preterm, 17 term wheezing.
- Both wheezing groups had lower lung function than controls.
- Term infants showed worse lung function (e.g., FEV0.5) and greater bronchodilator response than preterm infants.
Conclusions:
- Young children with recurrent wheezing, especially term infants, have impaired lung function.
- Term infants exhibit greater bronchodilator responsiveness, aiding diagnosis and treatment strategies.
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