Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

2.9K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.9K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.5K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.5K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.5K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.5K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

909
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
909
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.2K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.2K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

2.8K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An integrated lifestyle-, genetic- and metabolomics-based prediction model for mild cognitive aging in the HCHS/SOL.

NPJ dementia·2026
Same author

Tox21mer, A transformer foundation model for Tox21 high-throughput concentration-response curves data.

bioRxiv : the preprint server for biology·2026
Same author

Smoking drives an epigenetic memory of aberrant hematopoiesis.

medRxiv : the preprint server for health sciences·2026
Same author

An Ensemble Classifier for Ordinal Outcomes in High-Dimensional Genomics Data.

Pharmaceutical statistics·2026
Same author

Pipe and cigar use, lung function decline and clinical outcomes: an analysis of the NHLBI Pooled Cohorts Study.

Thorax·2026
Same author

Proteomic Profiling of Pulmonary Function and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study.

Journal of the American Heart Association·2026

Related Experiment Video

Updated: Nov 6, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

7.0K

Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.

Sinjini Sikdar1,2, Annah B Wyss2, Mi Kyeong Lee2

  • 1Department of Mathematics and Statistics, Old Dominion University, Norfolk, Virginia, USA.

Thorax
|May 8, 2021
PubMed
Summary

Genetic Risk Scores (GRS) reveal that genetic susceptibility significantly impacts reduced pulmonary function, especially in smokers and individuals with asthma. This highlights gene-environment interactions in respiratory health.

Keywords:
asthmarespiratory measurementtobacco and the lung

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

593
Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
09:25

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Published on: January 10, 2015

11.6K

Related Experiment Videos

Last Updated: Nov 6, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

7.0K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

593
Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
09:25

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Published on: January 10, 2015

11.6K

Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Environmental Health

Background:

  • Genome-wide association studies (GWASs) have identified numerous genetic loci linked to reduced pulmonary function.
  • Pulmonary function is influenced by smoking, asthma, and environmental factors like dust endotoxin.
  • Previous studies found limited evidence for gene-environment interactions at the single nucleotide polymorphism (SNP) level.

Purpose of the Study:

  • To investigate gene-environment interactions influencing pulmonary function using Genetic Risk Scores (GRSs).
  • To assess if GRSs enhance the power to detect interactions between genetic susceptibility and environmental factors (smoking, asthma, dust endotoxin) on pulmonary function.

Main Methods:

  • Analysis of 2844 European ancestry individuals from a US agricultural cohort with GWAS data.
  • Construction of weighted GRSs for pulmonary function traits (FEV1, FVC, FEV1/FVC) using top GWAS variants.
  • Linear regression models were used to assess associations between GRSs and traits, and to test for interactions with smoking status, asthma, and dust endotoxin exposure.

Main Results:

  • Pulmonary function traits were significantly associated with their respective GRSs (p < 8.9x10^-8).
  • The association between GRS and reduced FEV1/FVC was stronger in current smokers (p_interaction=0.017) and former smokers (p_interaction=0.064) compared to never smokers.
  • A significant interaction was observed between GRS and asthma status (p_interaction=0.053), indicating greater genetic impact on pulmonary function in asthmatics.

Conclusions:

  • GRS evaluation supports a significant gene-environment interaction between genetic susceptibility and smoking/asthma.
  • Increased genetic predisposition exacerbates the negative effects of smoking and asthma on pulmonary function.
  • No significant interactions were found between GRS and house dust endotoxin exposure.