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Agonal elevation in serum digoxin concentrations in infants and children long after cessation of therapy
1Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada.
Critical Care Medicine
|August 1, 1988
Abstract:
In 11 of 15 profoundly sick, digitalized infants and children, elevation in serum digoxin concentration could be detected long after cessation of therapy. This phenomenon concurred with a rapid deterioration of renal function. Because death of a digitalized child may be attributed to the glycoside itself, it is important to recognize that elevation in serum concentration to a potentially toxic level is a common pathophysiologic pattern.