Related Experiment Video
Updated: Nov 6, 2025
06:25
Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
9.7K
B Cell Lymphomas of the GI Tract
Sara Small1, Liron Barnea Slonim2, Corinne Williams3
1Division of Hematology/Oncology, Northwestern University, Chicago, IL, USA.
Current Gastroenterology Reports
|May 8, 2021
Summary
Primary gastrointestinal (GI) B cell lymphomas are diverse. This review covers diagnosis, features, and management of diffuse large B cell lymphoma (DLBCL), marginal zone lymphomas (MZL), and other GI lymphomas.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Primary gastrointestinal (GI) lymphomas of B cell origin represent a heterogeneous group of malignancies.
- Understanding their diverse nature is crucial for effective clinical management.
Purpose of the Study:
- To provide a comprehensive overview of the diagnosis, pathologic and molecular features, and management of primary GI B cell lymphomas.
- To highlight the unique aspects of these lymphomas compared to their nodal counterparts.
Main Methods:
- Literature review and synthesis of current knowledge on primary GI B cell lymphomas.
- Discussion of diagnostic criteria, histopathological subtypes, and molecular characteristics.
Main Results:
- The most common types include diffuse large B cell lymphoma (DLBCL) and marginal zone lymphomas (MZL).
- Other types such as follicular lymphoma (FL), mantle cell lymphoma (MCL), post-transplant lymphoproliferative disorders (PTLD), and Burkitt lymphoma also occur in the GI tract.
- While sharing similarities with nodal lymphomas, primary GI lymphomas possess unique clinical and biological features.
Conclusions:
- Diagnostic and treatment strategies are continuously evolving based on new discoveries.
- Ongoing research into pathophysiology and molecular characteristics is improving the management of these diverse GI lymphomas.
Related Concept Videos
01:18Lymphoid Cells and Tissues
2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K
01:15Secondary Lymphoid Organs
7.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.6K
01:16Primary Lymphoid Organs
13.1K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
13.1K
01:17Chronic Bowel Disorders: Introduction
600
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
600
01:27Histology of the Small Intestine
2.4K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
2.4K
01:20Histology of the Gastrointestinal (GI) Tract
2.2K
The GI tract, from beginning to end, is made up of four continuous tissue layers that adjust their structure according to their specific roles. These layers, from innermost to outermost, are known as the mucosa, submucosa, muscularis, and serosa, which are continuous with the mesentery.
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...
2.2K