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Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research
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Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research

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Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges

Thoria Donia1, Abeer Khamis2

  • 1Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.

Environmental Science and Pollution Research International
|May 8, 2021
PubMed

Insights

Oxidative stress and inflammation are key drivers of cardiovascular diseases (CVDs), contributing to plaque formation. This review explores their interplay, biomarkers, lifestyle impacts, and genetic influences on CVD risk.

Area of Science:

  • Biomedical Science
  • Cardiology
  • Molecular Biology

Background:

  • Cardiovascular diseases (CVDs) share common etiologies, notably the interplay of oxidative stress and inflammation.
  • These processes are crucial in the development of atherosclerotic plaques.

Purpose of the Study:

  • To elucidate the crosstalk between oxidative stress, inflammation, and CVD.
  • To review mitochondrial roles, prevention strategies, biomarkers, lifestyle impacts, genetic susceptibility, and omics technologies related to CVD.
  • To explore oxidative stress-related microRNAs and epigenetic modifications.

Main Methods:

  • Literature review focusing on the pathophysiology of CVDs.
  • Analysis of laboratory biomarkers and physiological tests for oxidative stress and inflammation.
  • Exploration of omics technologies and microRNA involvement.

Main Results:

  • A strong link exists between oxidative stress, inflammation, and CVD pathogenesis.
  • Mitochondrial dysfunction plays a role in this crosstalk.
  • Healthy lifestyles can mitigate CVD onset and progression.

Conclusions:

  • Understanding the redox and inflammatory basis of CVD is crucial for prevention.
  • Individual variability in CVD risk is influenced by genetic susceptibility and assessed through advanced omics technologies.
  • Epigenetic modifications and microRNAs are emerging areas in CVD research.

Keywords:
AntioxidantsCardiovascular diseaseInflammationOmicsOxidative stressRedox biomarkersRisk factorsmiRNA

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