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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Updated: Nov 6, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Comments on the evolution of TRPV6.

Karin Wolske1, Amanda Wyatt1, Ulrich Wissenbach1

  • 1Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421 Homburg, Saar, Germany.

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
|May 8, 2021
PubMed
Summary
This summary is machine-generated.

The Transient Receptor Potential Vanilloid 6 (TRPV6) ion channel shows evolutionary differences between species. Human TRPV6 gene variations are linked to pancreatitis and skeletal dysplasia, effects not seen in mice.

Keywords:
Calcium channelPancreatitisProstate cancerSkeletal dysplasiaTRPV6Transient receptor potential

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Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Genetics

Background:

  • Biological findings in animals do not always translate to humans.
  • The Transient Receptor Potential Vanilloid 6 (TRPV6) protein exemplifies inter-species differences due to parallel evolution.
  • TRPV6, a calcium-selective ion channel, has ancient origins with homologs in archaebacteria.

Purpose of the Study:

  • To explore the evolutionary pathways and inter-species differences of the TRPV6 protein.
  • To investigate the functional implications of TRPV6 variations in humans compared to other species.

Main Methods:

  • Comparative genomics analysis to trace TRPV6 evolution.
  • Examination of gene duplication and loss events in TRPV5/6 evolution.
  • Correlation analysis of TRPV6 allele inactivation with human diseases.

Main Results:

  • TRPV6 and TRPV5 evolved through gene duplication from ancient TRPV6-like sequences.
  • Placental mammals exhibit an N-terminal extension in TRPV6, altering translation initiation.
  • Human TRPV6 allele inactivation is associated with alcohol-independent pancreatitis and skeletal dysplasia, unlike in mice.

Conclusions:

  • TRPV6 evolution showcases parallel evolutionary pathways and species-specific adaptations.
  • Human genetic variations in TRPV6 have significant health implications, highlighting species-specific disease susceptibility.
  • The pronounced effects of TRPV6 perturbations in humans underscore the importance of inter-species research considerations.