Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

964
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
964
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

727
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
727

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical Spectral Transmission Imaging in Patients with Osteoarthritis: A Comparative Study with Joint Ultrasound and Clinical Markers.

Rheumatology and therapy·2026
Same author

Carotid-femoral pulse wave velocity improves cardiovascular risk prediction beyond SCORE2 in autoimmune rheumatic diseases: a 7-year follow-up study.

RMD open·2026
Same author

Longitudinal cognitive assessment using the Cumulus NeuLogiq platform in amyotrophic lateral sclerosis and frontotemporal dementia.

Scientific reports·2026
Same author

Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control.

NPJ Parkinson's disease·2026
Same author

Multi-dimensional characterization and tracking of motor unit action potentials.

Journal of neural engineering·2026
Same author

Color Doppler carotid resistance, pulsatility, and aortic oscillometry indices in giant cell arteritis: insights from the VASCARD cohort.

Arthritis research & therapy·2026

Related Experiment Video

Updated: Nov 6, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.0K

Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis.

Roisin McMackin1, Stefan Dukic1, Emmet Costello1

  • 1Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.

Neurobiology of Aging
|May 8, 2021
PubMed
Summary

Amyotrophic Lateral Sclerosis (ALS) disrupts brain networks, altering attention switching. This study reveals progressive hyperactivity in specific regions and hyperactivity decline in others, correlating with cognitive and motor impairments.

Keywords:
Amyotrophic lateral sclerosisCognitionElectroencephalographyHyperexcitabilityLongitudinalNetwork

More Related Videos

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.1K
Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

8.4K

Related Experiment Videos

Last Updated: Nov 6, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.0K
Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.1K
Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

8.4K

Area of Science:

  • Neuroscience
  • Electrophysiology
  • Neurodegenerative Diseases

Background:

  • Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease impacting motor neurons.
  • Cognitive and behavioral impairments are increasingly recognized in ALS patients.
  • Understanding brain network changes in ALS is crucial for diagnosis and treatment.

Purpose of the Study:

  • To quantitatively characterize progressive brain network disruption in ALS during cognition.
  • To investigate changes in cortical source activity using mismatch negativity (MMN) as an electrophysiological index of attention switching.
  • To correlate these network changes with cognitive, behavioral, and motor decline, as well as survival rates.

Main Methods:

  • Longitudinal 128-channel electroencephalography (EEG) recording in 60 ALS patients and cross-sectional EEG in 62 healthy controls.
  • Mismatch negativity (MMN) measurement to assess attention switching.
  • Dipole fitting and linearly constrained minimum variance beamforming for cortical source activity analysis.

Main Results:

  • ALS patients showed lower baseline activity in the inferior frontal gyri (IFG) compared to controls.
  • Progressive hyperactivity was observed in the right IFG and superior temporal gyri (STG) in ALS patients over time.
  • Initial hyperactivity in left motor and dorsolateral prefrontal cortices declined progressively in ALS.
  • Baseline motor hyperactivity correlated with cognitive disinhibition; reduced IFG activity correlated with motor decline; left dorsolateral prefrontal activity predicted cognitive impairment.
  • Reduced baseline IFG and STG activity, and later STG hyperactivation, correlated with shorter survival.

Conclusions:

  • Source-resolved EEG effectively characterizes symptom-associated and symptom-preceding cortical network decline in ALS.
  • Brain network disruptions in ALS involve both progressive hyperactivity and hyperactivity decline in distinct regions.
  • These network alterations are linked to cognitive, behavioral, and motor impairments, and impact patient survival.