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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.4K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.7K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

2.4K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
108
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.1K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Related Experiment Video

Updated: Nov 6, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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[Diabetes and COVID-19].

Béatrice Bouhanick1, Jean-Luc Cracowski2, Jean-Luc Faillie3

  • 1Pôle cardiovasculaire et métabolique, service d'HTA et de thérapeutique, CHU Rangueil, TSA 50032, 1, avenue J.- Poulhes, 31059 Toulouse cedex 9, France; UMR 1027, université Toulouse III, 31000 Toulouse, France.

Therapie
|May 9, 2021
PubMed
Summary

Diabetes may increase COVID-19 severity, but it is not a direct risk factor for infection. This review examines dipeptidylpeptidase-4 (DPP-4) inhibitors and their role in managing diabetes during the pandemic.

Keywords:
COVID-19DPP-4 inhibitorsDiabetesDiabèteEpidemiologyInhibiteurs des DPP-4RecommandationsRecommendationsÉpidémiologie

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Area of Science:

  • Virology
  • Endocrinology
  • Immunology

Context:

  • COVID-19 has been linked to severe outcomes in diabetic patients.
  • The role of diabetes as a direct risk factor for SARS-CoV-2 infection remains unclear.
  • Limited data exists on the impact of antidiabetic drugs during the pandemic.

Purpose:

  • To discuss whether diabetes itself is a risk factor for SARS-CoV-2 infection.
  • To review the function of dipeptidylpeptidase-4 (DPP-4) in viral infections.
  • To analyze the use and implications of DPP-4 inhibitors in diabetic patients with COVID-19.

Summary:

  • Dipeptidylpeptidase-4 (DPP-4) is a protein involved in cellular processes and viral entry.
  • The study explores the potential link between DPP-4 inhibitors and COVID-19 outcomes in individuals with diabetes.
  • Current French and international recommendations for diabetes management during the pandemic are discussed.

Impact:

  • Provides insights into the complex relationship between diabetes, COVID-19, and antidiabetic therapies.
  • Highlights the potential role of DPP-4 in viral pathogenesis.
  • Informs clinical practice and public health strategies for managing diabetic populations during viral outbreaks.