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Microfluidic formulation of nanoparticles for biomedical applications.

Sarah J Shepherd1, David Issadore2, Michael J Mitchell3

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Biomaterials
|May 9, 2021
PubMed
Summary

Microfluidics offers a scalable solution for producing highly consistent nanoparticle (NP) formulations, overcoming limitations of traditional methods. This technology enhances NP properties for advanced therapeutic and diagnostic applications.

Keywords:
Drug deliveryImagingMicrofluidicsNanoparticle

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanomedicine has advanced clinical applications due to nanoparticle (NP) advantages like biocompatibility and potency.
  • Approved NP therapies exist for imaging, drug, and gene delivery, but scalability and targeting efficiency remain challenges.
  • Current NP formulation methods suffer from batch variability and poor dispersity.

Purpose of the Study:

  • To review advances in microfluidic technologies for nanoparticle formulation.
  • To highlight the potential of microfluidics in addressing current NP formulation challenges.
  • To analyze future outlooks in microfluidic NP formulation.

Main Methods:

  • Review of microfluidic devices for nanoparticle formulation.
  • Emphasis on lipid-based, polymeric, and inorganic nanoparticles.
  • Analysis of microfluidic device advantages, challenges, and emerging trends.

Main Results:

  • Microfluidics enables reproducible NP formulations with controlled physical properties (size, distribution, loading efficiency).
  • Microfluidic-generated NPs show enhanced properties for biomedical applications compared to bulk techniques.
  • Microfluidics offers solutions for batch variability and dispersity issues in NP production.

Conclusions:

  • Microfluidics presents a promising technology for overcoming current limitations in nanoparticle formulation.
  • Future directions include scale-independent production via device parallelization and multi-step reactions.
  • Microfluidic approaches are crucial for advancing therapeutic and diagnostic nanomedicine.