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Related Experiment Video

Updated: Nov 6, 2025

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

Regular physical exercise mediates the immune response in atherosclerosis.

André F do Brito Valente¹, Richard T Jaspers¹, Rob Ci Wüst¹

¹Laboratory for Myology, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Exercise Immunology Review

|May 9, 2021

Summary

Regular exercise reduces atherosclerosis by lowering inflammation through immune system modulation and altered myokine levels. This review explores how exercise impacts cardiovascular disease pathophysiology.

Keywords:

FGF21 IL-6 adiponectin atherosclerosis cytokines exercise myokines

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Published on: September 26, 2018

Area of Science:

Cardiovascular Disease Research
Immunology
Exercise Physiology

Background:

Atherosclerosis is a chronic inflammatory disease characterized by plaque buildup in blood vessels, potentially leading to restricted blood flow.
The immune system significantly influences plaque rupture in atherosclerosis.
The precise mechanisms by which regular exercise combats atherosclerosis pathophysiology remain unclear.

Purpose of the Study:

To review the mechanisms through which regular exercise modulates atherosclerosis.
To discuss how exercise lowers systemic inflammation via immune system and myokine alterations.
To examine exercise-induced responses of myokines and innate immune cell function.

Main Methods:

Literature review focusing on exercise, inflammation, and atherosclerosis.
Analysis of immune system modulation by exercise.
Examination of myokine (IL-6, adiponectin, FGF21) responses to exercise.

Main Results:

Regular exercise can decrease systemic inflammation through direct immune system modulation.
Exercise influences atherosclerosis indirectly via changes in myokine concentrations and metabolites.
Specific myokines like IL-6, adiponectin, and FGF21 show altered responses to exercise.

Conclusions:

Regular exercise offers anti-inflammatory benefits relevant to atherosclerosis.
Exercise modulates innate immune cell function, impacting plaque formation.
Understanding these mechanisms can lead to novel therapeutic strategies for cardiovascular disease.