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Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
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The Mononuclear Phagocyte System of the Rat
David A Hume1, Melanie Caruso2, Sahar Keshvari2
1Mater Research Institute-University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia David.Hume@uq.edu.au Katharine.Irvine@uq.edu.au.
Journal of Immunology (Baltimore, Md. : 1950)
|May 9, 2021
Summary
The laboratory rat is a valuable model for studying human diseases. This review highlights the mononuclear phagocyte system (MPS) in rats, offering tools and knowledge for future research.
Area of Science:
- Immunology
- Cell Biology
- Animal Models
Background:
- The mononuclear phagocyte system (MPS), comprising monocytes, macrophages, and dendritic cells, plays crucial roles in tissue homeostasis and immunity.
- While mice are commonly used, technological advancements diminish their unique advantages as a model organism.
- Understanding MPS function is vital for studying inflammation and human diseases.
Purpose of the Study:
- To review the available tools for studying the rat MPS.
- To summarize the current knowledge on rat MPS development, homeostasis, regulation, and diversity.
- To advocate for the rat as a superior model for MPS research.
Main Methods:
- Literature review of existing studies on rat MPS.
- Analysis of technological advancements and resources applicable to rat MPS research.
- Synthesis of current knowledge on MPS biology in rats.
Main Results:
- The rat is a well-established model for physiology and behavior research.
- MPS cells are critical for immune responses and tissue maintenance.
- Advances in technology now support comprehensive MPS studies in rats.
Conclusions:
- The laboratory rat offers significant advantages for studying the mononuclear phagocyte system.
- A review of current tools and knowledge supports the rat as a model for MPS research.
- Further research utilizing the rat model will advance understanding of immunity and disease.
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