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Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated
Todd Karsies1, Keiko Tarquinio2, Steven L Shein3
1Division of Pediatric Critical Care, Nationwide Children's Hospital, Columbus, OH.
Insights
Clinician adherence to antibiotic guidelines for pediatric ventilator-associated infections remains low, with respiratory cultures often prioritized over evidence-based recommendations. This led to prolonged ventilation and hospital stays.
Area of Science:
- Pediatric critical care medicine
- Infectious disease management
- Antibiotic stewardship
Background:
- Ventilator-associated infection (VAI) is a significant concern in pediatric intensive care units (PICUs).
- Optimizing antibiotic use is crucial to combat resistance and improve patient outcomes.
Purpose of the Study:
- To evaluate the effectiveness and safety of a guideline for antibiotic decisions in children with suspected VAI.
- To assess clinician adherence to the guideline and its impact on antibiotic utilization and patient outcomes.
Main Methods:
- A prospective, observational cohort study was conducted in 22 PICUs across the United States and Canada.
- A consensus guideline for antibiotic management at 48-72 hours was developed and implemented in two phases.
- Data on demographic, clinical, microbiologic, and outcome variables were collected.
Main Results:
- Guideline-concordant antibiotic management was observed in 70% of subjects post-implementation, compared to 76% pre-implementation.
- Illness severity and positive respiratory cultures were key factors influencing antibiotic continuation, overriding guideline recommendations in many cases.
- Antibiotic continuation, particularly when not supported by the guideline, was associated with longer durations of mechanical ventilation and PICU stay.
Conclusions:
- Clinician failure to adhere to the antibiotic guideline, often due to reliance on respiratory culture results, limits its efficacy.
- Strategies to address clinician perceptions and other barriers are essential for improving guideline adherence and antibiotic stewardship in VAI.
- Further research is needed to enhance the impact of guidelines on antibiotic use in pediatric VAI.
Objectives:
To evaluate a guideline for antibiotic decisions in children with suspected ventilator-associated infection.
Design:
Prospective, observational cohort study conducted in 22 PICUs in the United States and Canada.
Setting:
PICUs in 22 hospitals from April 2017 to January 2019.
Subjects:
Children less than 3 years old on mechanical ventilation greater than 48 hours who had respiratory secretions cultured and antibiotics initiated for suspected ventilator-associated infection.
Interventions:
After baseline data collection in children with suspected ventilator-associated infection (Phase 1), a consensus guideline was developed for advising antibiotic continuation or stopping at 48-72 hours (Phase 2) and implemented (Phase 3). Guideline-based antibiotic recommendations were provided to the treating clinicians once clinical and microbiologic data were available. Demographic and outcome data were collected, and guideline compliance and antibiotic utilization evaluated for Phase 1 and Phase 3.
Measurements And Main Results:
Despite education and implementation efforts, guideline-concordant antibiotic management occurred in 158 of 227 (70%) Phase 3 subjects compared with 213 of 281 (76%) in Phase 1. Illness severity and positive respiratory cultures were the primary determinants of antibiotic continuation. For subjects with a positive respiratory culture but a score for which antibiotic discontinuation was recommended (score ≤ 2), only 27% of Phase 3 subjects had antibiotics discontinued. Antibiotic continuation was not associated with improved outcomes in these subjects and was associated with significantly longer duration of ventilation (median 5.5 d longer) and PICU stay (5 d longer) in the overall study population. Positive respiratory cultures were not associated with outcomes irrespective of antibiotic treatment.
Conclusions:
Antibiotic guideline efficacy and safety remain uncertain due to clinician failure to follow the guideline, instead primarily relying on respiratory culture results. Strategies to overcome clinician perceptions of respiratory cultures and other barriers will be vital for improving guideline adherence and antibiotic use in suspected ventilator-associated infection in future studies.
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