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Updated: Nov 6, 2025

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Diurnal rhythms and obesity.

Georgios K Paschos¹

¹Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Current Opinion in Clinical Nutrition and Metabolic Care

|May 9, 2021

Summary

Disturbed diurnal rhythms are linked to obesity. Restoring these rhythms through timed eating shows promise in reversing obesity and improving metabolic health.

Area of Science:

Chronobiology
Metabolic Health
Obesity Research

Background:

Obesity and diabetes are associated with disrupted circadian and metabolic rhythms in adipose tissue.
Environmental factors like high-fat diets and shift work exacerbate these rhythm disturbances.
Research highlights the link between disturbed diurnal rhythms and increased adiposity.

Purpose of the Study:

To review recent studies on the role of disturbed diurnal rhythms in obesity development.
To examine the efficacy of timed feeding strategies in restoring diurnal rhythms and combating obesity.

Main Methods:

Analysis of studies in human patients with obesity and diabetes.
Inclusion of findings from animal models investigating environmental disturbances.

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Last Updated: Nov 6, 2025

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

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Published on: June 13, 2025

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

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Published on: December 16, 2022

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Review of human studies on the impact of feeding timing on metabolic health.

Main Results:

Evidence shows that disturbed diurnal rhythms contribute to obesity.
Time-restricted feeding in animal models demonstrates rhythm restoration and obesity reversal.
Human studies confirm the importance of feeding time for metabolic health.

Conclusions:

Disturbed diurnal rhythms are implicated in obesity development.
Restoring diurnal rhythms through strategic feeding times can reverse obesity.
Further research may refine dietary guidelines based on circadian biology.