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Ticagrelor Increases Platelet-Mediated Staphylococcus aureus Killing, Resulting in Clearance of Bacteremia

Erlinda R Ulloa1,2, Satoshi Uchiyama3, Robert Gillespie4

  • 1Department of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA.

The Journal of Infectious Diseases
|May 9, 2021
PubMed

Platelets are a critical immune defense against Staphylococcus aureus bloodstream infections. Staphylococcus aureus α-toxin is a virulence factor that decreases platelet viability and accelerates platelet clearance. It has been shown that ticagrelor blocks α-toxin-mediated platelet injury and resulting thrombocytopenia, protecting mice in a lethal S. aureus sepsis model. We now present the use of ticagrelor as adjunctive therapy in a patient with a S. aureus endovascular infection and thrombocytopenia, associated with restoration of platelet count and bacteremia clearance. Ticagrelor enhanced platelet killing of the S. aureus bloodstream isolate from the treated patient in vitro.

Keywords:
Staphylococcus aureusMSSA bacteremiaendovascular infectionsinnate immunityplateletsticagrelor

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