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Controlled release of pharmaceutical agents using eutectic modified gelatin.

Wanwan Qu1, Idrees B Qader2, Andrew P Abbott3

  • 1School of Chemistry, University of Leicester, Leicester, LE1 7RH, UK.

Drug Delivery and Translational Research
|May 9, 2021
PubMed
Summary
This summary is machine-generated.

Pharmaceutical deep eutectic solvents (PDESs) enhance drug delivery by increasing solubility and absorption. Formulations using PDESs with gelatin show increased oral and transdermal uptake rates for active pharmaceutical ingredients (APIs).

Keywords:
And drug deliveryDeep eutectic solventsDissolution rateSolubility

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Drug Delivery Systems

Background:

  • Deep eutectic solvents (DESs) are mixtures of hydrogen bond donors and acceptors, exhibiting unique properties like reduced melting points and enhanced solubility.
  • Active pharmaceutical ingredients (APIs) often have high melting points, limiting their solubility and bioavailability.
  • The formation of DESs can improve the physicochemical properties of APIs, facilitating their incorporation into delivery systems.

Purpose of the Study:

  • To formulate pharmaceutical deep eutectic solvents (PDESs) using imipramine HCl, ascorbic acid, and catechol.
  • To investigate the effect of these PDESs on the plasticization of gelatin.
  • To evaluate the enhanced oral and transdermal delivery of APIs from PDES-plasticized gelatin.

Main Methods:

  • Formulation of PDESs from selected APIs and suitable hydrogen bond donors/acceptors.
  • Incorporation of PDESs into gelatin matrices to create plasticized materials.
  • Assessment of API dissolution rates in aqueous media.
  • Evaluation of transdermal drug release from PDES-loaded patches.

Main Results:

  • PDES formulations significantly increased the dissolution rates of imipramine HCl, ascorbic acid, and catechol compared to pure APIs.
  • Gelatin plasticized with PDESs demonstrated improved API uptake.
  • Transdermal delivery studies showed a substantial increase in imipramine HCl release (65%) from PDES-based patches compared to the pure drug (20%) within 15 minutes.

Conclusions:

  • Pharmaceutical deep eutectic solvents are effective in enhancing the solubility and dissolution rates of APIs.
  • PDES-plasticized gelatin serves as a promising platform for improving both oral and transdermal drug delivery.
  • The developed PDES systems offer a viable strategy for overcoming bioavailability challenges associated with poorly soluble APIs.