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Updated: Nov 6, 2025

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic

Lei Ma^1,2, J Sebastian Garcia-Medina¹, Geisa Ortet¹

¹Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.

Advances in Experimental Medicine and Biology

|May 9, 2021

Summary

Neuronal deletion of hypoxia-inducible factors (HIFs) impaired cognitive and motor functions during hypoxic adaptation. This suggests HIFs are crucial for how the brain responds to low oxygen conditions.

Keywords:

Chronic hypoxia Cognitive function Hypoxia-inducible factors Hypoxic adaptation Motor function

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Published on: November 2, 2015

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Last Updated: Nov 6, 2025

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Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

Published on: November 2, 2015

Area of Science:

Neuroscience
Physiology
Molecular Biology

Background:

Hypoxia-inducible factors (HIFs) are key transcriptional regulators.
HIFs, specifically HIF-1 and HIF-2, play critical roles in cellular responses to low oxygen.
Understanding neuronal HIF function is vital for comprehending hypoxic adaptation.

Purpose of the Study:

To investigate the impact of neuronal HIF-1 and HIF-2 deletion on hypoxic adaptation.
To assess behavioral and physiological changes in mice lacking neuronal HIFs under hypoxia.

Main Methods:

Utilized neuron-specific knockout (KO) mice with deleted HIF-1 and HIF-2.
Exposed mice to hypobaric hypoxia (8% oxygen) for 3 weeks.
Evaluated cognitive function (Y-maze), motor function (rotarod, grip strength), and hematocrit.

Main Results:

Neuronal HIF deletion did not alter the significant increase in hematocrit observed in both control and KO mice under hypoxia.
KO mice showed a trend towards lower cognitive function (Y-maze alternation rate) after hypoxia.
KO mice exhibited significantly reduced motor performance (rotarod latency) following hypoxic exposure.

Conclusions:

Neuronal deficiency of HIF-1 and HIF-2 appears to negatively affect behavioral performance during hypoxic adaptation.
These findings highlight the importance of neuronal HIFs in mediating adaptive responses to low oxygen environments.