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Appearance of interfrontal bone in chimeric mouse.

K Fukuta¹, N Goto, T Inoue

¹National Institute of Animal Health, Ibaraki, Japan.

Jikken Dobutsu. Experimental Animals

|April 1, 1988

Summary

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The presence of the interfrontal bone in mice depends on the C57BL/6 cell population, not on interactions between C57BL/6 and BALB/c cells during development.

Area of Science:

Developmental biology
Genetics
Skeletal biology

Background:

The interfrontal bone incidence varies between mouse strains, notably high in C57BL/6 and low in BALB/c.
Previous studies indicate strain-specific differences in interfrontal bone formation.

Purpose of the Study:

To investigate the role of cellular interaction in the morphogenesis of the interfrontal bone using aggregation chimeras.
To determine if genetically distinct cells (C57BL/6 and BALB/c) interact during interfrontal bone development.

Main Methods:

Generation of aggregation chimeras from C57BL/6 and BALB/c mouse strains.
Analysis of interfrontal bone incidence and size in parent strains, F1 crosses, and chimeras.
Assessment of chimerism using coat color mosaicism and glucose phosphate isomerase (G PI) analysis.

Related Experiment Videos

Main Results:

C57BL/6 mice predominantly exhibited large interfrontal bones, while BALB/c and F1 crosses showed low incidence of large or tiny bones.
Chimeric mice frequently developed large interfrontal bones, with size correlating to the proportion of C57BL/6 cells.
Mice with a dominant C57BL/6 cell population had large interfrontal bones; those with a BALB/c predominance had none or tiny bones.

Conclusions:

Interfrontal bone formation is directly associated with the presence and dominance of C57BL/6 cells within the skeletal rudiment.
There is no evidence of interaction between C57BL/6 and BALB/c cells influencing interfrontal bone morphogenesis.