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VCP/p97 cofactor UBXN1/SAKS1 regulates mitophagy by modulating MFN2 removal from mitochondria

Chantal Mengus1, Melanie Neutzner1, Ana Catarina Pinho Ferreira Bento1

  • 1Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Autophagy
|May 10, 2021
PubMed
Summary

UBXN1 is a VCP cofactor crucial for PINK1/PRKN-dependent mitophagy. Loss of UBXN1 impairs mitochondrial VCP/PRKN translocation and MFN2 removal, hindering mitophagy initiation and maintenance.

Keywords:
MFN2PRKNUBXN1UBXN6VCPmitophagy

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