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Is there any relationship between platelet indices and myocarditis in children?

Damla Geçkalan Soysal1, Rahmi Özdemir2

  • 1Kütahya Health Sciences University, Department of Pediatrics, Kütahya, Turkey.

Cardiology in the Young
|May 10, 2021
PubMed

Insights

Platelet indices like plateletcrit may aid in myopericarditis prognosis in children. Platelet count and plateletcrit increased significantly after treatment, showing a negative correlation with troponin I and C-reactive protein levels.

Area of Science:

  • Pediatric Cardiology
  • Hematology
  • Inflammatory Diseases

Background:

  • Platelet indices (plateletcrit, MPV, PDW) reflect platelet activation and function.
  • These indices can be altered in inflammatory conditions.
  • Their prognostic value in pediatric myopericarditis is under investigation.

Purpose of the Study:

  • To investigate the utility of platelet indices as prognostic indicators in pediatric myopericarditis.
  • To compare platelet indices in children with myopericarditis, respiratory infections, and healthy controls.
  • To assess changes in platelet indices following treatment for myopericarditis.

Main Methods:

  • A cohort of 60 children was divided into myopericarditis, respiratory infection, and control groups.
  • Complete blood count, C-reactive protein, and troponin levels were analyzed.
  • Myopericarditis diagnosis was based on clinical, ECG, cardiac biomarkers, and echocardiographic findings.
  • Platelet indices were compared at diagnosis and 2 weeks post-treatment in myopericarditis patients.

Main Results:

  • No significant difference in baseline platelet indices between groups.
  • A statistically significant increase in platelet count and plateletcrit was observed after myopericarditis treatment.
  • A negative correlation was found between platelet/plateletcrit values and troponin I/C-reactive protein levels.

Conclusions:

  • Platelet count and plateletcrit values increase post-treatment in pediatric myopericarditis.
  • This finding suggests a potential role for these platelet parameters in managing pediatric myopericarditis.
  • This is the first study to explore platelet indices for myopericarditis prognosis in children.
Abstract

Keywords:
Myopericarditschildrenplatelet indicesplateletcrit

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