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Bempedoic acid. Mechanism of action and pharmacokinetic and pharmacodynamic properties
Lluís Masana Marín1, Núria Plana Gil1
1Unitat de Medicina Vascular i Metabolisme. Hospital Universitari Sant Joan. Universitat Rovira I Virgili. IISPV. CIBERDEM, Reus, España.
Abstract:
Bempedoic acid acts by inhibiting adenosine triphosphate-citrate lyase (ACL) and consequently cholesterol biosynthesis, leading to increased expression of LDL receptors and increasing low-density lipoproteins (LDL-C) plasma clearence. It is a prodrug for oral administration with intracellular activation. It is activatedin liver cells and to a lesser extent in kidney cells, being absent in adipose tissue and muscle cells. Therefore, unlike statins, its potential myotoxic effect is very limited. It has recently been approved as a lipid-lowering drug in combination with diet, with statins, or with other lipid-lowering drugs in patients with hypercholesterolaemia, mixed dyslipidaemia, statin intolerance, or when these are contraindicated. The marketing of bempedoic acid implies, in clinical practice, having a new family of lipid-lowering drugs.
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