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Comparing calculated and experimental activity and dose values obtained from image-based quantification of 90Y
Konrad Lotter1, Markus Diemling2, Antti Sohlberg2
1Technische Universität Wien - Technical University of Vienna, Karlsplatz 13, 1040 Wien, Austria.
Zeitschrift Fur Medizinische Physik
|May 10, 2021
Summary
This study validates a novel quantitative imaging method for 90Y dosimetry in selective internal radiation therapy (SIRT). The approach ensures reliable and traceable dose measurements for liver tumors, improving treatment accuracy.
Area of Science:
- Nuclear Medicine
- Medical Physics
- Radiotherapy
Background:
- Selective Internal Radiation Therapy (SIRT) uses 90Y microspheres for liver tumors.
- Accurate post-treatment dosimetry is crucial for effective SIRT.
- Quantitative imaging is essential for reliable dosimetry.
Purpose of the Study:
- To validate a Monte Carlo-based reconstruction software for quantitative 90Y dosimetry.
- To assess the accuracy of SPECT/CT imaging for measuring activity and dose after SIRT.
- To establish an uncertainty budget for 90Y dosimetry.
Main Methods:
- Utilized Monte Carlo software with scatter, attenuation, and collimator corrections for 90Y bremsstrahlung SPECT/CT.
- Analyzed data from 17 patients and various phantoms (Jaszczak, NEMA, anthropomorphic liver).
- Compared measured activities and doses with applied activities and pre-treatment calculations.
Main Results:
- Measurements were repeatable within the established uncertainty.
- Reconstruction parameters had negligible influence on results.
- Phantom measurements showed good agreement with calculated values after partial volume correction.
Conclusions:
- Metrological requirements and an uncertainty budget enhance the reliability of 90Y dosimetry.
- Demonstrated successful voxel-based dosimetry using quantitative 90Y SPECT/CT.
- This method provides a traceable approach for post-treatment SIRT dosimetry.
