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Related Experiment Video

Updated: Nov 6, 2025

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Osteotomy in the newborn classic bladder exstrophy patient: A comparative study.

Preeya Khandge1, Wayland J Wu1, Saran A Hall1

  • 1Robert D. Jeffs Division of Pediatric Urology, James Buchanan Brady Urological Institutions, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Charlotte Bloomberg Children's Hospital, Baltimore, MD, USA.

Journal of Pediatric Urology
|May 10, 2021
PubMed
Summary

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The effect of neonatal partial upper and lower urinary tract obstruction on the intestinal microbiome in a murine animal model.

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Multidisciplinary perioperative management of cloacal exstrophy bladder closure: A single institution's approach.

Journal of pediatric urology·2026

Pelvic osteotomy is safe for newborns undergoing classic bladder exstrophy (CBE) closure, with low complication rates comparable to delayed closures. This procedure aids bladder closure in infants with wide pubic diastasis.

Area of Science:

  • Pediatric Urology
  • Orthopedic Surgery
  • Neonatal Surgery

Background:

  • Classic bladder exstrophy (CBE) often requires pelvic osteotomy for closure, especially with wide pubic diastasis.
  • Safety data for pelvic osteotomy in newborns undergoing CBE closure is less established than in delayed closures.

Purpose of the Study:

  • To evaluate the safety and efficacy of pelvic osteotomy in newborns with CBE undergoing primary bladder closure.
  • To compare outcomes and complications of pelvic osteotomy in newborn versus delayed CBE closures.

Main Methods:

  • A retrospective review of a prospectively maintained IRB-approved database of CBE patients who underwent pelvic osteotomy during primary closure.
  • Patients were categorized into newborn (<28 days) and delayed (>28 days) closure groups.
Keywords:
ExstrophyNewborn closurePelvic osteotomy

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  • Outcomes included closure success rates and orthopedic/non-orthopedic complications; analyses used Chi-square tests.

    • Main Results:

    • 286 patients (186 newborn, 100 delayed) were analyzed. Overall success rates varied by osteotomy type in newborns (71.4% anterior innominate) and significantly in delayed closures (93.8% anterior innominate).
    • Febrile urinary tract infection was the most common complication (8%).
    • Orthopedic complications were rare (1.7%), with no significant difference in rates between newborn and delayed closure groups.

    Conclusions:

    • Pelvic osteotomy can be safely performed in newborns with CBE, exhibiting low orthopedic complication rates.
    • Despite trends favoring delayed closure, osteotomy remains a viable and safe option for select newborn CBE cases.