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Updated: Nov 6, 2025

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Published on: October 24, 2018
Renal replacement therapy during extracorporeal membrane oxygenation
Balasubramanian Subbarayan1, Vadamalai Vivek1, Madhan Kumar Kuppuswamy1
1Apollo Hospitals Chennai, Chennai, Tamil Nadu India.
Extracorporeal membrane oxygenator (ECMO) use is rising, often leading to acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). This review covers CRRT basics, indications, ECMO integration, and patient outcomes.
Area of Science:
- Critical Care Medicine
- Nephrology
- Cardiovascular Engineering
Background:
- Extracorporeal membrane oxygenator (ECMO) utilization has surged in the last two decades.
- Acute kidney injury (AKI) is a frequent complication in patients supported by ECMO.
- A significant proportion of ECMO patients necessitate continuous renal replacement therapy (CRRT).
Purpose of the Study:
- To review the fundamental principles of CRRT.
- To outline the indications for initiating CRRT in ECMO patients.
- To discuss the technical integration of CRRT with ECMO circuits and associated clinical outcomes.
Main Methods:
- Review of existing literature on CRRT and ECMO.
- Analysis of technical considerations for combining CRRT and ECMO.
- Examination of clinical data and outcomes for patients receiving both therapies.
Main Results:
- High incidence of AKI in ECMO patients.
- Prevalence of CRRT requirement among ECMO patients.
- Data on clinical management and outcomes are presented.
Conclusions:
- CRRT is essential for managing AKI in ECMO patients.
- Successful integration of CRRT with ECMO requires careful technical planning.
- Understanding clinical aspects and outcomes is crucial for optimizing patient care.
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