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The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer

Yaheng Li1, Chuanyin Li1, Shuyuan Liu1

  • 1Department of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China.

International Journal of Medical Sciences
|May 10, 2021
PubMed

Insights

Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes are linked to cervical cancer development. This review explores miRNA SNPs

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Cervical cancer is a major global health concern, ranking as the fourth most common gynecological malignancy and cause of cancer death in women.
  • MicroRNAs (miRNAs) are crucial noncoding RNA molecules regulating gene expression posttranscriptionally and are implicated in cervical cancer pathogenesis.
  • Single nucleotide polymorphisms (SNPs) within miRNA genes can affect miRNA function and are associated with various cancers, including cervical cancer.

Purpose of the Study:

  • To review the current research on the role of single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes in the development of cervical cancer.
  • To summarize the progress in understanding miRNA SNPs in cervical cancer.
  • To elucidate the molecular mechanisms underlying the regulation of miRNA SNPs in cervical cancer.

Main Methods:

  • Literature review of studies investigating miRNA SNPs and cervical cancer.
  • Analysis of research on the functional impact of miRNA SNPs on miRNA biogenesis and activity.
  • Synthesis of data on the association between specific miRNA SNPs and cervical cancer risk and progression.

Main Results:

  • Identified specific miRNA SNPs associated with altered miRNA expression and maturation.
  • Summarized evidence linking certain miRNA SNPs to increased susceptibility or progression of cervical cancer.
  • Highlighted the molecular pathways through which miRNA SNPs may influence cervical cancer development.

Conclusions:

  • miRNA SNPs represent a significant genetic factor influencing cervical cancer development.
  • Further research into miRNA SNPs could reveal novel biomarkers and therapeutic targets for cervical cancer.
  • Understanding the molecular mechanisms of miRNA SNPs is crucial for advancing cervical cancer prevention and treatment strategies.
Keywords:
cervical cancermiRNAsregulationsingle nucleotide polymorphisms

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