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Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis

Fitri Fareez Ramli1, Muhammad Hasif Azizi2, Syed Alhafiz Syed Hashim1

  • 1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, Malaysia.

International Journal of Medical Sciences
|May 10, 2021
PubMed

Insights

Treatments like bupropion, trazodone, Rosa Damascena, and ginseng show promise for improving sexual dysfunction in patients undergoing opioid substitution therapy (OST). Adverse effects were minimal, suggesting a safe therapeutic option for this population.

Area of Science:

  • Pharmacology
  • Sexual Health
  • Addiction Medicine

Background:

  • Sexual dysfunction is prevalent among individuals receiving opioid substitution therapy (OST).
  • Addressing sexual dysfunction is crucial for improving the overall well-being and treatment adherence in the OST population.

Purpose of the Study:

  • To evaluate the efficacy and safety of various treatments for sexual dysfunction in patients undergoing OST.
  • To synthesize evidence from interventional studies on pharmacological and herbal interventions.

Main Methods:

  • Systematic literature search of Medline, PubMed, and Scopus for interventional studies.
  • Inclusion of five randomized-controlled trials and two quasi-experimental studies.
  • Risk-of-bias assessment using RoB 2 by three independent authors.
  • Meta-analysis conducted for bupropion's effect on male sexual function.

Main Results:

  • Seven studies involving 473 patients were identified, examining bupropion, trazodone, Rosa Damascena, and ginseng.
  • Bupropion, trazodone, Rosa Damascena, and ginseng demonstrated significant improvements in various sexual functioning domains for both genders.
  • Meta-analysis confirmed bupropion significantly enhanced male sexual function (SMD = 0.53, P < 0.01).
  • All treatments exhibited minor adverse effects with no significant differences compared to placebo in RCTs.

Conclusions:

  • Bupropion, trazodone, Rosa Damascena, and ginseng are promising therapeutic options for sexual dysfunction in the OST population.
  • These agents appear safe with minimal adverse effects.
  • Further research with larger sample sizes is warranted to confirm these findings and guide clinical practice.
Keywords:
bupropionginsengmethadoneopioidsrosa Damascenasexual dysfunctiontrazodone

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