Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

2.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

116
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
116
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

158
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
158
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

516
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
516
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

212
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
212
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.7K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double versus single emergency cervical cerclage combined with vaginal progesterone: a multicenter, non-blinded, randomized controlled trial.

American journal of obstetrics and gynecology·2026
Same author

Prenatal ultrasonography diagnosis of urinary tract duplication in female fetus.

Ginekologia polska·2026
Same author

Role of Ultrasound and Fetal MRI in the Prenatal Assessment of Congenital Cytomegalovirus Infection: A Systematic Review.

Journal of clinical medicine·2026
Same author

Navigating hypertriglyceridemia in pregnancy: current evidence and clinical strategies.

Frontiers in endocrinology·2026
Same author

Safety of biopsy in phaeochromocytoma and paraganglioma: an international, multicentre, retrospective cohort study.

The lancet. Diabetes & endocrinology·2026
Same author

Pituitary carcinoma: a diagnostic labyrinth in a rare endocrinopathy.

Endokrynologia Polska·2026

Related Experiment Video

Updated: Nov 6, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

9.9K

Cyclic Cushing's Syndrome - A Diagnostic Challenge.

Renata Świątkowska-Stodulska1, Agata Berlińska1, Katarzyna Stefańska2

  • 1Department of Endocrinology and Internal Medicine, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Frontiers in Endocrinology
|May 10, 2021
PubMed
Summary

Cyclic Cushing's syndrome presents diagnostic challenges due to fluctuating cortisol levels. This study explores diagnostic algorithms, including hair cortisol analysis and desmopressin tests, to aid in identifying this rare endocrine disorder.

Keywords:
DDAVP testcyclic Cushing’s syndromecyclic hypercortisolemiadesmopressin testdiagnosis of Cushing’s syndromehair cortisol

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.8K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.5K

Related Experiment Videos

Last Updated: Nov 6, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

9.9K
A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.8K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.5K

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Clinical Diagnostics

Background:

  • Cyclic Cushing's syndrome involves alternating periods of high (hypercortisolemia) and normal/low (normo-/hypocortisolemia) cortisol levels.
  • Diagnosis requires at least three hypercortisolemic episodes separated by two normocortisolemic periods.
  • This condition poses significant diagnostic challenges due to its variable presentation and unpredictable phases.

Purpose of the Study:

  • To discuss a diagnostic algorithm for cyclic Cushing's syndrome.
  • To highlight the utility of specific diagnostic tools for intermittent hypercortisolemia.

Main Methods:

  • Review of diagnostic criteria for cyclic Cushing's syndrome.
  • Evaluation of hair cortisol analysis as a diagnostic marker.
  • Assessment of the desmopressin stimulation test in diagnosing periodic hypercortisolemia.

Main Results:

  • The unpredictable nature of cyclic Cushing's syndrome complicates diagnosis.
  • Hair cortisol analysis offers a potential method for detecting past hypercortisolemia.
  • The desmopressin stimulation test may aid in identifying underlying adrenal dysfunction.

Conclusions:

  • Diagnosing cyclic Cushing's syndrome requires a structured approach.
  • Hair cortisol testing and desmopressin stimulation are valuable adjuncts to traditional diagnostic methods.
  • Further research into optimized diagnostic algorithms is warranted for this challenging endocrine disorder.