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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
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Related Experiment Video

Updated: May 1, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Gastrointestinal dysfunction in systemic mastocytosis. A prospective study.

J A Cherner1, R T Jensen, A Dubois

  • 1Digestive Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland.

Gastroenterology
|September 1, 1988
PubMed
Summary

Gastrointestinal issues like ulcers and acid hypersecretion are common in systemic mastocytosis. These symptoms are linked to increased histamine but not altered gut transit.

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Hematology

Background:

  • Systemic mastocytosis (SM) is a rare disorder characterized by abnormal mast cell proliferation.
  • Gastrointestinal (GI) symptoms are frequently reported in SM patients, but their underlying mechanisms are not fully understood.

Purpose of the Study:

  • To prospectively evaluate GI functions in patients with systemic mastocytosis.
  • To investigate the relationship between GI functions and the occurrence of GI symptoms in SM.

Main Methods:

  • Prospective evaluation of GI functions in 16 consecutive SM patients.
  • Assessment included duodenal ulcer/duodenitis, gastric acid secretion, small intestinal absorption, and GI transit time (mouth-to-cecum).
  • Plasma histamine, gastrin, and vasoactive intestinal peptide levels were measured.

Main Results:

  • 80% of SM patients experienced GI symptoms (abdominal pain or diarrhea).
  • Duodenal ulcers/duodenitis and gastric acid hypersecretion were common; increased histamine correlated with basal acid output.
  • Altered GI transit was not identified as a cause for symptoms; mild malabsorption was observed in some patients.

Conclusions:

  • GI symptoms, peptic disease, and mild malabsorption are more prevalent in SM than previously recognized.
  • Dyspeptic pain is associated with acid-peptic disease and hypersecretion; significant diarrhea may also involve hypersecretion.
  • Altered GI transit does not appear to be a primary factor in the pathogenesis of these GI symptoms in SM.