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Updated: Nov 6, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
PRELIMINARY STUDY ON SKIN CANCER DETECTION IN SENCAR MICE USING MUELLER OPTICAL COHERENCE TOMOGRAPHY
Miloš Todorović1, Shuliang Jiao2, George Stoica3
1Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843-3120, USA.
Abstract:
We report on the use of a fiber-based Mueller-matrix optical coherence tomography (OCT) system with continuous source-polarization modulation for in vivo imaging of early stages of skin cancer in SENCAR mice. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. The OCT images show the morphological changes in skin resulting from pre-cancerous papilloma formations that are consistent with histology, thus demonstrating the system's potential for early skin cancer detection.
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