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Related Concept Videos

Penis01:29

Penis

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The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
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The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Nov 6, 2025

Microscopic Replantation of Penile Glans Amputation Due to Circumcision
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Pseudoangiosarcomatous squamous cell carcinoma: first case report on penis.

Liseana O Barbosa1, José Osvaldo B Neto2, Antônio Augusto L Teixeira-Júnior3

  • 1Laboratory Immunofluorescence and Electron Microscopy, University Hospital Universitário Presidente Dutra, São Luís, MA, Brazil.

Translational Andrology and Urology
|May 10, 2021
PubMed
Summary

This study reports the first case of pseudoangiosarcomatous squamous cell carcinoma of the penis, an aggressive cancer variant. This finding is crucial for diagnosing penile lesions, especially when mimicking vascular tumors.

Keywords:
Pseudoangiosarcomacase reporthuman papillomaviruspenile cancersquamous cell carcinoma

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Area of Science:

  • Oncology
  • Dermatopathology

Background:

  • Pseudoangiosarcomatous squamous cell carcinoma (PASC) is a rare, aggressive variant of squamous cell carcinoma.
  • It is characterized by atypical keratinocytes forming pseudovascular spaces, distinct from true vascular tumors.

Observation:

  • This study details the first documented case of PASC involving the penis.
  • The patient presented with a painful penile lesion and urinary retention, with extensive local infiltration.

Findings:

  • Microscopic examination revealed a sarcomatous keratinocyte proliferation mimicking vascular spaces.
  • Human papilloma virus (HPV) and polymerase chain reaction (PCR) tests were negative.
  • The case demonstrated advanced penile squamous cell carcinoma with aggressive lymph node metastasis.

Implications:

  • This case highlights PASC as a critical differential diagnosis for penile malignancies.
  • Accurate histological identification is essential for appropriate patient management and treatment strategies.