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Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers

Zitong Yang1, Qinchen Li1, Xiangyi Zheng1

  • 1Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Oncology
|May 10, 2021
PubMed

Insights

Long noncoding RNAs (lncRNAs), specifically small nucleolar RNA host genes (SNHGs), are increasingly implicated in urological cancers. This review explores their roles and mechanisms in these malignancies.

Area of Science:

  • Urology
  • Molecular Oncology
  • Genetics

Background:

  • Urological cancer incidence is rising, with current diagnostics and treatments facing limitations.
  • Long noncoding RNAs (lncRNAs) are crucial in various cancers, including urological malignancies.
  • Small nucleolar RNA host genes (SNHGs), a lncRNA subgroup, show dysregulation in tumor biology.

Purpose of the Study:

  • To review the impact of lncRNA SNHGs in urological cancers.
  • To elucidate the underlying mechanisms of SNHG involvement in urological malignancies.

Main Methods:

  • Literature review of studies on lncRNA SNHGs and urological cancers.
  • Analysis of existing research on SNHG dysregulation and function in tumor progression.
  • Synthesis of data on SNHG mechanisms in carcinogenesis and treatment response.

Main Results:

  • SNHGs are significantly dysregulated in various urological cancers.
  • lncRNA SNHGs influence key processes such as proliferation, metastasis, and drug resistance.
  • Specific SNHGs have been identified as potential biomarkers and therapeutic targets.

Conclusions:

  • lncRNA SNHGs represent a critical area of study in urological oncology.
  • Understanding SNHG mechanisms can lead to improved diagnostic and therapeutic strategies.
  • Targeting SNHGs holds promise for future urological cancer treatments.
Keywords:
SNHGbladder cancerkidney cancerlncRNAprostate cancer

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