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Updated: Nov 6, 2025

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Primary diffuse large B-cell lymphoma of the CNS, with a "Lymphomatosis cerebri" pattern
Balamurugan Thirunavukkarasu1, Kirti Gupta1, Ritu Shree2
1Post Graduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.
Abstract:
We describe an unusual case of lymphomatosis cerebri in a middle-aged lady presenting with rapid-onset dementia. The lymphomatous infiltrate, instead of forming mass lesions, percolated throughout the brain parenchyma, which is often missed on a stereotactic biopsy and hence warrants caution and awareness about this entity. The nonspecific symptoms at presentation and a variable picture at imaging make this entity diagnostically challenging.

