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Updated: Nov 6, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
Published on: March 5, 2022
The m6A Consensus Motif Provides a Paradigm of Epitranscriptomic Studies
Kun Wang1, Jinying Peng1, Chengqi Yi1,2,3
1State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Abstract:
To date more than 150 kinds of RNA chemical modifications have been identified in cellular RNAs, among which N6-methyladenosine (m6A) is the most prevalent mRNA modification in higher eukaryotes. m6A is widely conserved among eukaryotes and tends to occur in a RRACH consensus motif. This consensus motif is identified as early as the 1970s and positively influences the subsequent epigenetic studies. This viewpoint discusses the discovery of this m6A consensus motif and the latest studies around it.
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