Related Experiment Video
Updated: Nov 6, 2025

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Bringing Down the Door-to-needle Time: Patient Thrombolysed in 6 Minutes-A Case Report
Introduction:
It has been clearly established that thrombolysis using recombinant tissue plasminogen activator is strongly beneficial for acute stroke patients. The sensitivity of brain tissue to ischemia causes this time dependence on the effectiveness of recombinant tissue plasminogen activator. Early recognition of stroke and activation of a stroke alert/code are imperative to treat acute stroke patients effectively and to realize positive outcomes.
Case Presentation:
A 68-year-old man with right-sided weakness arrived at our emergency room and was thrombolysed in 6 minutes from time of arrival, after ruling out all contraindications.
Conclusion:
The case and our rapid thrombolysis protocol that helped in achieving the 6-minute door-to-needle time are described. A structured protocol is recommended to reduce door-to-needle times for thrombolysis in acute ischemic stroke.
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