Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.3K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.3K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.7K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.2K
3.2K
Ribosome Profiling02:24

Ribosome Profiling

3.8K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.8K
Genomics02:02

Genomics

38.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
38.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<sup>13</sup>C NMR as a foundation for machine learning models of polysaccharides.

Structural dynamics (Melville, N.Y.)·2026
Same author

Resolving heterogeneity in Lymph Node Stromal Cells using high-dimensional analysis of non-optimized flow cytometry data.

Frontiers in bioinformatics·2026
Same author

Efficient long-term cryopreservation of Arthrospira platensis NIES-39 and adaptation for the Space Algae-2 spaceflight experiment.

NPJ microgravity·2026
Same author

Cellular Characterization Using Microwave-Assisted Immunocytochemistry, A Time-Efficient Alternative to Traditional Immunocytochemistry.

Current protocols·2026
Same author

Mass Spectrometric Determination of Site-Specific <i>O</i>-Acetylation in Rhamnogalacturonan I Oligomers.

Journal of the American Society for Mass Spectrometry·2026
Same author

Biochemical characterization of xyloglucan galactosyltransferases MUR3 and XLT2 from Spirodela polyrhiza.

The Plant journal : for cell and molecular biology·2026

Related Experiment Video

Updated: Nov 6, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.8K

Accelerating Biological Insight for Understudied Genes.

Kimberly A Reynolds1, Eduardo Rosa-Molinar2, Robert E Ward3

  • 1The Green Center for Systems Biology and the Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Integrative and Comparative Biology
|May 10, 2021
PubMed
Summary
This summary is machine-generated.

Annotating newly discovered protein-coding genes is crucial for understanding life and biotechnology. A collaborative, interdisciplinary approach across multiple species can accelerate functional gene annotation and overcome research biases.

More Related Videos

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.4K
Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

13.8K

Related Experiment Videos

Last Updated: Nov 6, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.8K
Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.4K
Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

13.8K

Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Genome sequencing is rapidly identifying new protein-coding genes.
  • Current annotation relies heavily on sequence conservation, often lacking specific functional details.
  • Understudied genes present opportunities for discovery but face research biases.

Purpose of the Study:

  • To propose a novel research model for accelerating the functional annotation of understudied protein-coding genes.
  • To overcome traditional research silos and biases in biological functional annotation.
  • To leverage advances in experimental techniques and multi-species analysis.

Main Methods:

  • Developing coordinated, interdisciplinary projects involving evolutionary biologists, cell biologists, geneticists, and biochemists.
  • Focusing on specific subsets of target genes across multiple model organisms.
  • Utilizing concurrent analysis in different species to exploit evolutionary divergence and selection.

Main Results:

  • Concurrent analysis in multiple organisms enhances the suitability of species as experimental models for specific genes.
  • Multi-system approaches foster transdisciplinary critical thinking and hypothesis testing.
  • This model aims to accelerate the pace of biological functional annotation.

Conclusions:

  • A collaborative, multi-species research model is essential for efficient functional gene annotation.
  • Breaking down research silos and biases is key to unlocking the potential of newly discovered genes.
  • This initiative will advance our understanding of evolution, biochemistry, and biotechnology targets.