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Related Concept Videos

Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

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Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
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Three primary contributing factors have been identified.
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This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Related Experiment Video

Updated: Nov 6, 2025

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
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COVID-19 in the tonsillectomised population.

Vincenzo Capriotti1, Francesco Mattioli2, Francesco Guida1

  • 1Otorhinolaryngology-Head and Neck Surgery Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|May 10, 2021
PubMed
Summary
This summary is machine-generated.

A history of tonsillectomy may predict more severe COVID-19 symptoms, including fever and malaise. This finding could help identify individuals at higher risk for intense systemic manifestations of SARS-CoV-2 infection.

Keywords:
COVID-19SARS-CoV-2coronavirustonsillectomytonsils

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Pharyngeal associated lymphoid tissue (PALT) plays a role in SARS-CoV-2 interactions.
  • Dysfunction of PALT may influence COVID-19 manifestations.
  • Tonsillectomy serves as a surrogate for PALT dysfunction.

Purpose of the Study:

  • To investigate if a history of tonsillectomy predicts COVID-19 presentation and course.
  • To assess the association between tonsillectomy and SARS-CoV-2 infection outcomes.

Main Methods:

  • Multicentric cross-sectional observational study.
  • Data collected from 779 adult SARS-CoV-2 positive patients across seven Italian hospitals.
  • Analysis included clinical course, symptoms, and demographic data in relation to tonsillectomy history.

Main Results:

  • Patients with prior tonsillectomy had a higher risk of fever (>39°C), chills, and malaise.
  • No significant difference in hospital admission rates was observed between groups.
  • Tonsillectomy history correlated with more intense systemic symptoms.

Conclusions:

  • Tonsillectomy history indicates PALT immunological dysfunction.
  • This dysfunction predicts more severe systemic COVID-19 manifestations.
  • Tonsillectomy history may serve as a simple clinical marker for risk stratification and prognostic modeling in COVID-19.