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CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.

Christopher J Arthurs1, Rostislav Khlebnikov1, Alex Melville2

  • 1King's College London, London, United Kingdom.

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|May 10, 2021
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Summary
This summary is machine-generated.

The CRIMSON software environment enables advanced computational hemodynamics studies. This system integrates image segmentation, modeling, simulation, and analysis for cardiovascular research and clinical applications.

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Area of Science:

  • Biomedical Engineering
  • Computational Fluid Dynamics
  • Medical Imaging Analysis

Background:

  • Computational hemodynamics is crucial for understanding cardiovascular diseases.
  • Existing tools often lack integration, user-friendliness, or accessibility for clinicians and students.
  • There is a need for a comprehensive, open-source platform for cardiovascular modeling and simulation.

Purpose of the Study:

  • To introduce the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment.
  • To provide a powerful, customizable, and user-friendly system for 3D and reduced-order computational hemodynamics studies.
  • To make advanced computational hemodynamics tools accessible to researchers, clinicians, and students globally.

Main Methods:

  • Vascular structure segmentation from medical images.
  • Analytic arterial and venous geometric model construction.
  • Finite element mesh generation, boundary condition application, and incompressible Navier-Stokes simulations with fluid-structure interaction.
  • Post-processing and visualization of blood flow, pressure, and wall shear stress fields.

Main Results:

  • CRIMSON offers a complete pipeline from image segmentation to results visualization.
  • The software leverages open-source standards for broad compatibility and accessibility.
  • It has been successfully applied to diverse clinical problems, including surgical planning and medical device optimization.

Conclusions:

  • CRIMSON is a versatile and accessible software environment for computational hemodynamics.
  • Its integrated approach facilitates complex cardiovascular modeling and simulation.
  • The platform supports advancements in clinical practice and medical device development through accessible simulation tools.