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Updated: Nov 6, 2025

Author Spotlight: Microscopic Analysis of Protein Localization at Plasmodesmata in Plants
Published on: November 1, 2024
Structural and functional characteristics of plant PHD domain-containing proteins
Tian Yi Wang1, Ying Xiang Wang1, Chen Jiang You1
1Institute of Plant Science, College of Life Science, Fudan University, Shanghai 200433, China.
Abstract:
Plant homeodomain (PHD) is a class of transcription factor in the Zinc finger domain family. The most important function of which is to recognize various histone modifications, including histone methylation and acetylation, etc. They can also bind to DNA. Proteins with PHD domains, some of which possess histone modification enzyme activity, or can interact with histone modification enzymes, and some are associated with DNA methylation, with E3 ubiquitin ligase activity, or even can be chromatin remodeling factors. As transcriptional regulators, they play an important role in plant growth and development. In this review, we summarize the structural features and substrate binding specificity of PHD domains (including H3K4me3/0, H3K9me3, H3R2, H3K14ac) and DNA, the conservation of plant PHD domain in evolution, the molecular mechanism of known PHD domain-containing proteins in plants, providing a reference for further understanding of the involvement of these proteins during plant growth and development.
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