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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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MDMPR: Mouse Developmental and Metabolic Phenotype Repository.

Wen Jing Zhu1, Zhi Wei Liu1

  • 1Cambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China.

Yi Chuan = Hereditas
|May 11, 2021
PubMed
Summary

The Mouse Developmental and Metabolic Phenotype Repository (MDMPR) provides open access to mouse models and phenotype data. This initiative aims to accelerate research in developmental and metabolic diseases by centralizing resources and data.

Keywords:
Mouse Development and Metabolic Phenotype Repositoryopen-access sharing platformresource repository

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Area of Science:

  • Developmental Biology
  • Metabolic Research
  • Genomics and Bioinformatics

Background:

  • The Mouse Developmental and Metabolic Phenotype Repository (MDMPR) is established to address the need for centralized mouse resources and phenotype data.
  • Existing research in developmental and metabolic regulation requires comprehensive and accessible datasets.
  • The project is funded by the Ministry of Science and Technology of the People's Republic of China.

Purpose of the Study:

  • To create a comprehensive, open-access, real-time database for mouse developmental and metabolic phenotype data.
  • To generate 500 novel mutant mouse models for developmental and metabolic research.
  • To integrate diverse biological databases for enhanced data accessibility and research acceleration.

Main Methods:

  • Development of integrated sub-systems including ES cell, project management, breeding, sperm bank, and phenotyping databases.
  • Standardized phenotyping analysis of mutant mouse models.
  • Digitalization and real-time data management for authenticity and accessibility.

Main Results:

  • Establishment of a multi-system repository for mouse resources and phenotype data.
  • Creation of a growing collection of mutant mouse models and associated phenotyping data.
  • Integration of external databases like human KO ES cell, STRING, and transcriptional regulatory circuitries.

Conclusions:

  • MDMPR serves as a crucial one-stop resource for developmental and metabolic research.
  • The repository aims to accelerate scientific discovery by providing convenient access to mouse models and data.
  • This initiative is expected to significantly contribute to understanding and treating human health conditions related to development and metabolism.