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Tracking adoptive T cell immunotherapy using magnetic particle imaging.

Angelie Rivera-Rodriguez¹, Lan B Hoang-Minh^2,3, Andreina Chiu-Lam⁴

¹J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL USA.

Nanotheranostics

|May 11, 2021

Summary

This summary is machine-generated.

Magnetic Particle Imaging (MPI) non-invasively tracks adoptively transferred T cells for cancer immunotherapy. This method aids in monitoring T cell accumulation in brain tumors, accelerating the development of effective adoptive cellular therapy (ACT) strategies.

Keywords:

biomedical imaging brain cancer cell labeling cellular therapy iron oxide nanoparticles

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Area of Science:

Immunology and Cancer Therapy
Medical Imaging and Diagnostics

Background:

Adoptive cellular therapy (ACT) shows promise for cancer treatment, particularly against blood cancers.
Challenges remain in applying ACT to solid tumors, with efficient T cell trafficking and persistence being critical hurdles.
Non-invasive tracking methods are needed to monitor T cell accumulation in tumors and optimize ACT strategies.

Purpose of the Study:

To evaluate Magnetic Particle Imaging (MPI) as a non-invasive tool for tracking adoptively transferred T cells in vivo.
To assess the feasibility of using MPI for monitoring T cell accumulation in a preclinical model of brain cancer.

Main Methods:

T cells were magnetically labeled for tracking.
MPI was employed to visualize and quantify labeled T cells in a mouse model of brain cancer.
In vitro assessment confirmed that magnetic labeling did not compromise T cell function.

Main Results:

Magnetic labeling of T cells was successfully achieved without compromising their in vitro anti-tumor activity.
MPI enabled non-invasive detection of adoptively transferred T cells within the brain following administration.
Both intravenous and intracerebroventricular administration routes allowed for MPI-based T cell tracking in the brain.

Conclusions:

MPI is a viable technology for non-invasively tracking adoptively transferred T cells in vivo.
This imaging approach can facilitate the assessment of T cell trafficking and accumulation in brain tumors.
MPI can accelerate the development and optimization of adoptive cellular therapy for brain cancers and potentially other solid tumors.