Related Experiment Video
Updated: Nov 6, 2025
05:23
Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
6.3K
Coronavirus: Pure Infectious Disease or Genetic Predisposition
Farzaneh Darbeheshti1,2, Hassan Abolhassani3,4,5, Mohammad Bashashati6,7
1Department of Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Advances in Experimental Medicine and Biology
|May 11, 2021
Summary
Genetic factors may influence susceptibility and severity of COVID-19. Research into host genetics, drawing parallels with SARS-CoV-1, aims to unravel the genetic predisposition puzzle for coronavirus disease 2019.
Area of Science:
- Virology
- Human Genetics
- Immunology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a novel disease with limited understood host effects.
- Host genetic factors significantly influence individual susceptibility to infectious diseases.
- SARS-CoV-1, genetically similar to SARS-CoV-2, offers insights into potential host-pathogen interactions.
Purpose of the Study:
- To explore the genetic susceptibility factors contributing to COVID-19.
- To investigate the role of host genetics in determining COVID-19 severity.
- To assemble evidence for a potential genetic predisposition model for COVID-19.
Main Methods:
- Review of existing literature on coronaviruses and host genetics.
- Analysis of genetic similarities between SARS-CoV-1 and SARS-CoV-2.
- Discussion of potential genetic predisposition models for COVID-19.
Main Results:
- Host genetic factors are implicated in differential susceptibility and severity of COVID-19.
- Virus entry receptors and immune/inflammation-related genes are key areas of investigation.
- Parallels with SARS-CoV-1 suggest shared genetic susceptibility pathways.
Conclusions:
- Understanding host genetic factors is crucial for predicting COVID-19 outcomes.
- Further research into genetic predisposition can inform personalized risk assessment and management strategies.
- Genetic susceptibility to COVID-19 is a complex interplay of viral, host, and environmental factors.
More Related Videos
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
17.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.2K
01:20Infection
9.5K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
9.5K
02:59Cancer Prevention
7.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.2K
01:26Factors Affecting the Risk of Infection
13.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
01:23Cystic Fibrosis: Pathogenesis
511
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
511
01:28Human Genetics
974
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
974